Effects of Roxadustat combined with Iron dextran in treatment of renal anemia patients with non-dialysis-dependent chronic kidney disease
Objective:To observe effects of Roxadustat combined with Iron dextran in treatment of renal anemia patients with non-dialysis-dependent chronic kidney disease.Methods:The clinical data of 198 renal anemia patients with non-dialysis-dependent chronic kidney disease admitted to this hospital from June 2020 to April 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,99 cases in each group.The control group was treated with Iron dextran,while the observation group was treated with Roxadustat on the basis of that of the control group.Both groups were treated continuously for 12 weeks.The clinical efficacy,the blood routine indexes[hemoglobin(Hb),red blood cell count(RBC)]levels,serum ferritin(SF)level,the inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.96%(95/99),which was higher than 84.85%(84/99)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of Hb,RBC and SF in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Roxadustat combined with Iron dextran in the treatment of the renal anemia patients with non-dialysis-dependent chronic kidney disease can improve the total effective rate of treatment,the levels of blood routine indexes and the level of SF,and reduce the levels of inflammatory factors.Moreover,it is superior to single Iron dextran treatment.
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