Application effects of Lidocaine combined with general anesthesia in patients undergoing bronchoscopy
Objective:To observe application effects of Lidocaine combined with general anesthesia in patients undergoing bronchoscopy.Methods:The clinical data of 116 patients who underwent bronchoscopy in this hospital from March 2022 to March 2023 were retrospectively analyzed.According to different anesthesia schemes,they were divided into observation group and control group,58 cases in each group.The control group was treated with general anesthesia,while the observation group was treated with Lidocaine combined with general anesthesia.The anesthetic effects,the bronchoscopy time,the anesthesia recovery time,the hemodynamic indexes[mean arterial pressure(MAP),heart rate]levels at different time points[before anesthesia(T0),1 min after anesthesia(T1),bronchoscopy into the glottis(T2),biopsy tissue(T3),anesthesia awake(T4)],the stress reaction indexes[adrenocorticotropic hormone(ACTH),cortisol(Cor),malondialdehyde(MDA)]levels before anesthesia and after the examination,and the incidence of adverse events were compared between the two groups.Results:The excellent and good rate of anesthesia in the observation group was 94.83%(55/58),which was higher than that in the control group(82.76%,48/58),and the difference was statistically significant(P<0.05).There was no statistically significant difference in the bronchoscopy time between the two groups(P>0.05).The anesthesia recovery time of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).At T1,the MAP and heart rate levels of the two groups were lower than those at T0,but those in the observation group were higher than those in the control group;at T2-T3,the fluctuation of MAP and heart rate levels in the observation group was smaller than those in the control group;at T4,the MAP level of the observation group was higher than that of the control group;the heart rate levels of the two groups were higher than those at T0,but that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).After the examination,the levels of Cor,MDA and ACTH in the two groups were higher than those before anesthesia,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 10.34%(6/58),which was lower than 34.48%(20/58)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Lidocaine combined with general anesthesia in the patients undergoing bronchoscopy can improve the excellent and good rate of anesthesia,shorten the anesthesia recovery time,stabilize the level of hemodynamic indexes,reduce the levels of stress reaction indexes and the incidence of adverse reactions.Moreover,it is superior to single general anesthesia.
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