Effects of femoral nerve block-assisted general anesthesia on postoperative pain and inflammatory response in patients undergoing total knee arthroplasty
Objective:To investigate effects of femoral nerve block-assisted general anesthesia on postoperative pain and inflammatory response in patients undergoing total knee arthroplasty(TKA).Methods:A prospective study was conducted on 120 patients who underwent TKA in this hospital from May 2022 to May 2023.According to the random number table method,these patients were divided into control group and study group,60 cases in each group.Both groups were treated with combined intravenous and inhalation anesthesia.The study group was given ultrasound-guided femoral nerve block before anesthesia induction(injection of 20 mL of 0.375%Ropivacaine hydrochloride),while the control group was injected with the same amount of normal saline.Sufentanil intravenous analgesia was given for 48 h after the surgery for the two groups.The intraoperative and postoperative Sufentanil dosage,the visual analogue scale(VAS)score 4-48 h after the surgery,the serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)]levels before and after the surgery,and the incidence of adverse reactions were compared between the two groups.Results:The intraoperative and the postoperative Sufentanil dosage levels in the study group were significantly less than those in the control group,and the differences were statistically significant(P<0.05).The VAS scores of the study group 4,12 and 24 h after the surgery were significantly lower than those of the control group,and the differences were statistically significant(P<0.05).24 h after the surgery,the levels of serum IL-6 and TNF-α in the two groups were higher than those before the surgery,but those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was 8.33%(5/60),which was lower than 28.33%(17/60)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Femoral nerve block-assisted general anesthesia for the TKA patients can reduce the dosage of opioids during perioperative period,reduce the incidence of adverse reactions and the levels of postoperative inflammatory factors,and reduce the degree of postoperative pain.Moreover,it is superior to simple general anesthesia.
Total knee arthroplastyFemoral nerve blockGeneral anesthesiaPostoperative painInflammatory response
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