Effects of Shenkang injection combined with continuous renal replacement therapy on patients with sepsis complicated with acute kidney injury
Objective:To observe effects of Shenkang injection combined with continuous renal replacement therapy(CRRT)in treatment of patients with sepsis complicated with acute kidney injury(AKI).Methods:The clinical data of 106 patients with sepsis and AKI admitted to this hospital from February 2021 to February 2023 were retrospectively analyzed.According to different treatment options,they were divided into control group and study group,53 cases in each.The control group was treated with CRRT,while the study group was treated with Shenkang injection on the basis of that of the control group.The clinical efficacy,the TCM syndrome scores before and after the treatment,the organ function injury degree[sequential organ failure assessment(SOFA)]score,the renal function indexes[cystatin C(CysC),serum creatinine(Scr),β2-microglobulin(β2-MG),blood urea nitrogen(BUN)]levels,the inflammatory factor[kidney injury molecule-1(KIM-1),soluble intercellular adhesion molecule-1(sICAM-1),C-reactive protein(CRP),neutrophil gelatinase-associated apolipoprotein(NGAL)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 94.34%(50/53),which was higher than 81.13%(43/53)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes and SOFA in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CysC,Scr,β2-MG and BUN in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of KIM-1,sICAM-1,CRP and NGAL in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the study group was 3.76%,which was lower than 15.04%in the control group,the difference was statistically significant(P<0.05).Conclusions:Shenkang injection combined with CRRT can improve the total effective rate and reduce the TCM syndrome scores,the SOFA scores,the renal function index levels,inflammatory factor levels and the incidence of adverse reactions in the patients with sepsis complicated with AKI.Moreover,it is superior to single CRRT treatment.
SepsisAcute kidney injuryShenkang injectionContinuous hemodialysisTCM syndrome scoreInflammatory factorsRenal function
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