Efficiency of combined detection of serum CEA,CA125 and CA19-9 levels in diagnosis of lung cancer
Objective:To analyze efficiency of combined detection of serum carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and carbohydrate antigen 19-9(CA19-9)levels in diagnosis of lung cancer.Methods:The clinical data of 90 patients with pulmonary nodules admitted to this hospital from August 2020 to July 2022 were retrospectively analyzed.According to the results of lung biopsy,they were divided into malignant group(n=58)and benign group(n=32).The clinical data of 50 healthy subjects in the same period were retrospectively analyzed and they were selected as the control group.The levels of serum CEA,CA125 and CA19-9 in the three groups were compared,and the levels of CEA,CA125 and CA19-9 in the patients with different clinical stages of lung cancer were compared.The receiver operating characteristic(ROC)curve was drawn to analyze the efficiencies of single and combined detection of serum CEA,CA125 and CA19-9 levels in the diagnosis of lung cancer.Results:The levels of serum CEA,CA125 and CA19-9 in the malignant group were higher than those in the benign group and the control group,the level of CA125 in the benign group was higher than that in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the CEA and CA19-9 levels between the benign group and the control group(P>0.05).The levels of serum CEA,CA125 and CA19-9 in the patients with stage Ⅳ were higher than those in stage Ⅰ,Ⅱ and Ⅲ,the patients with stage Ⅲ were higher than those in stage Ⅰ and Ⅱ,and the differences were statistically significant(P<0.05).The ROC curve showed that the area under the curve of single and combined detection of serum CEA,CA125 and CA19-9 levels in the diagnosis of lung cancer were 0.785,0.716,0.751 and 0.937,separately,and the combined detection had the highest diagnostic efficiency.Conclusions:The efficiency of combined detection of serum CEA,CA125 and CA19-9 levels in the diagnosis of lung cancer is higher than that of single detection of the three.
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