Value of quantitative analysis parameters of contrast-enhanced ultrasound in diagnosis of thyroid nodules
Objective:To analyzed value of quantitative analysis parameters of contrast-enhanced ultrasound(CEUS)in diagnosis of thyroid nodules.Methods:The clinical data of 124 patients with thyroid nodules admitted to this hospital from February 2020 to February 2022 were retrospectively analyzed.All patients were given CEUS examination.Using the pathological examination results as the"gold standard",the CEUS examination parameters[contrast agent transit time(MTT),peak intensity(Peak),time to peak(TIP)]levels of the patients with different types of thyroid nodules and different pathological features of thyroid malignant nodules were compared.Spearman correlation analysis was used to analyze the correlations among the CEUS quantitative analysis parameter levels and the malignant thyroid nodules with different pathological features.Results:The pathological examination showed that among the 124 patients with thyroid nodules,58 were benign and 66 were malignant.There was no significant difference in the MTT level among different thyroid nodules and surrounding normal tissues(P>0.05).The Peak level of the malignant nodules was lower than those of the benign nodules and the surrounding normal tissues,and that of the benign nodules was lower than that of the surrounding normal tissues;the TIP level of the malignant nodules was higher than those of the benign nodules and the surrounding normal tissues,and that of benign nodules was higher than that of surrounding normal tissues;and the differences were statistically significant(P<0.05).There was no statistically significant difference in the MTT level among the thyroid malignant nodules with different pathological features(P>0.05).The comparison of the Peak levels of the malignant thyroid nodules with different pathological features showed that that of the nodules with lymph node metastasis was lower than those without lymph node non-metastasis,that of those with clinical stage Ⅲ-Ⅳ was lower than that of those with stage Ⅰ-Ⅱ,and that of those with depth of invasion T3-T4 was lower than that of those with T1-T2;the comparison of the TIP levels in the thyroid malignant nodules with different pathological features showed that that of nodules with the lymph node metastasis was higher than that of those with without lymph node metastasis,that of those with clinical stage Ⅲ-Ⅳ was higher than that of those with stage Ⅰ-Ⅱ,and that of those with infiltration depth T3-T4 was higher than that of those with T1-T2;and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that the Peak level was negatively correlated with lymph node metastasis,clinical stage and depth of invasion(r<0,P<0.05),and the TIP level was positively correlated with lymph node metastasis,clinical stage and depth of invasion(r>0,P<0.05).Conclusions:CEUS quantitative analysis parameter levels can be applied to the diagnosis and evaluation of thyroid nodules.
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万方数据
