Predictive value of neutrophil/lymphocyte ratio and high-sensitivity C-reactive protein level for early neurological deterioration in patients with acute ischemic stroke
Objective:To investigate predictive value of neutrophil/lymphocyte ratio(NLR)and high-sensitivity C-reactive protein(hs-CRP)level for early neurological deterioration(END)in patients with acute ischemic stroke(AIS).Methods:The clinical data of 86 patients with AIS admitted to this hospital from September 2021 to December 2022 were retrospectively analyzed.All patients received intravenous thrombolytic therapy with Alteplase.END was defined as an increase in National Institutes of Health stroke scale(NIHSS)score≥4 within 72 h after thrombolysis.These patients were divided into deterioration group(n=21)and non-deterioration group(n=65)according to whether END occurred.The clinical data,the NLR and the hs-CRP levels at admission were compared between the two groups.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of NLR hs-CRP levels and combined detection for END.Results:The NLR value and the hs-CRP level in the deterioration group were higher than those in the non-deterioration group,and the differences were statistically significant(P<0.05).There were no significant differences in gender,age,underlying diseases,smoking history,drinking history,NIHSS score at admission,and time from onset to admission between the two groups(P>0.05).ROC curve analysis showed that the area under the curve of hs-CRP level,NLR single and combined detection in the prediction of END in the AIS patients was 0.726,0.712 and 0.870,separately,and the AUC of combined detection was higher than that of single detection.Conclusions:The NLR and the hs-CRP levels can predict the risk of END in the AIS patients,and the predictive value of combined detection is higher than that of single detection.
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