Comparison of effects of Minocycline and Calcium hydroxide paste and Camphor phenol in root canal therapy for patients with acute periapical periodontitis
Objective:To compare effects of Minocycline and Calcium hydroxide paste and Camphor phenol in root canal therapy for patients with acute periapical periodontitis.Methods:A prospective study was conducted on 122 patients with acute periapical periodontitis admitted to the hospital from February 2020 to January 2023.These patients were randomly divided into control group and observation group by using the coin tossing method,61 cases in each group.The control group was treated with Camphor phenol for root canal filling,while the observation group was treated with Minocycline and Calcium hydroxide paste for root canal filling.The clinical efficacy,the periodontal disease indexes[probing depth(PD),tooth mobility(MD),attachment loss(AL),gingival index(GI)]levels,the pain degree[visual analogue scale(VAS)]score,the gingival crevicular fluid inflammatory indexes[interleukin-6(IL-6),interleukin-8(IL-8),malondialdehyde(MDA)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.44%(57/61),which was higher than 75.41%(46/61)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of periodontal disease indexes PD,MD,AL,GI,the inflammatory indexes IL-6,IL-8,MDA and the VAS score in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Minocycline and Calcium hydroxide paste in the treatment of acute periapical periodontitis superior to Camphor phenol.It can relieve the pain,reduce the levels of inflammatory factors in gingival crevicular fluid,improve the periodontal disease index levels,and has good safety.
Acute periapical periodontitisRoot canal therapyMinocyclineCalcium hydroxide pasteCamphor phenolFilling material
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