Effects of Topiramate combined with Lamotrigine in treatment of patients with generalized tonic-clonic seizures of epilepsy
Objective:To observe effects of Topiramate combined with Lamotrigine in treatment of patients with generalized tonic-clonic seizures of epilepsy.Methods:80 patients with generalized tonic-clonic seizures of epilepsy admitted to Shangqiu Third People's Hospital from April 2021 to January 2023 were selected and divided into control group and observation group according to the random number table method,40 cases in each group.The control group was treated with Lamotrigine,while the observation group was treated with Topiramate on the basis of that of the control group.Both groups were treated continuously for 3 months.The clinical efficacy,the cognitive function[Montreal cognitive assessment(MoCA)]score,the nerve injury indexes[neuron-specific enolase(NSE),central nervous specific protein(S100β),glial fibrillary acidic protein(GFAP),brain-derived neurotrophic factor(BDNF)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.50%(37/40),which was higher than 75.00%(30/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the MoCA score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of NSE,S100β and GFAP in the observation group were lower than those in the control group,the level of BDNF was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Topiramate combined with Lamotrigine in the treatment of the patients with generalized tonic-clonic seizures can improve the total effective rate of treatment and the cognitive function scores and improve the levels of nerve injury index.Moreover,it is superior to single Lamotrigine treatment.
万方数据
维普
