Objective:To observe effects of Vildagliptin combined with Metformin in treatment of obese patients with type 2 diabetes mellitus.Methods:A prospective study was conducted on 102 obese patients with type 2 diabetes mellitus admitted to this hospital from January 2021 to January 2023.They were divided into observation group and control group according to the random number table method,51 cases in each.The control group was treated with Metformin,while the observation group was treated with Vildagliptin on the basis of that of the control group.The levels of glucose metabolism indexes[fasting blood glucose(FBG),2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c)],lipid metabolism indexes[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)],and the adiponectin and the chemotaxin before and after the treatment,the clinical efficacy,and the incidence of adverse reactions during the treatment were compared between the two groups.Results:After the treatment,the levels of FBG,2hPG,HbA1c,TC,TG and LDL-C in the observation group were lower than those in the control group,the level of HDL-C was higher than that in the control group,and the differences were statistically significant(P<0.05).The level of adiponectin in the observation group was higher than that in the control group,the level of chemotaxin was lower than that in the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 96.08%(49/51),which was higher than 74.51%(38/51)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Vildagliptin combined with Metformin in the treatment of the obese patients with type 2 diabetes mellitus can improve the total effective rate and the adiponectin levels,improve the levels of lipid metabolism indexes,and reduce the levels of glucose metabolism indexes and chemotaxins.Moreover,it is superior to single Metformin treatment.
关键词
2型糖尿病/肥胖/维格列汀/二甲双胍/脂联素/趋化素/糖脂代谢
Key words
Type 2 diabetes mellitus/Obesity/Vildagliptin/Metformin/Adiponectin/Chemotaxin/Glycolipid metabolism
维普
万方数据