Effects of Tacrolimus ointment combined with Desloratadine citrate disodium in treatment of patients with facial atopic dermatitis
Objective:To observe effects of Tacrolimus ointment combined with Desloratadine citrate disodium in treatment of patients with facial atopic dermatitis(AD).Methods:A prospective study was conducted on 86 patients with facial AD admitted to this hospital from January 2021 to September 2022.They were divided into observation group(n=43)and control group(n=43)by using the random number table method.The control group was treated with Desloratadine citrate disodium,while the observation group was treated with Tacrolimus ointment on the basis of that of the control group.The clinical efficacy,the scoring atopic dermatitis(SCORAD)score,the levels of inflammatory factors[interferon-γ(IFN-γ),interleukin(IL)-4,IL-17]before and after the treatment,the incidence of adverse reactions during the treatment,and the recurrence rate after 6 months of follow-up were compared between the two groups.Results:The total effective rate of the observation group was 97.67%(42/43),which was higher than 81.40%(35/43)of the control group,and the difference was statistically significant(P<0.05).After 1,2 and 3 weeks of treatment,the SCORAD scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of IFN-γ in the observation group was higher than that in the control group,the levels of IL-17 and IL-4 were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The recurrence rate of the observation group was 9.76%(4/41),which was lower than 37.50%(12/32)of the control group,and the difference was statistically significant(P<0.05).Conclusions:Tacrolimus ointment combined with Desloratadine citrate disodium in the treatment of the facial AD patients can improve the total effective rate of treatment,improve the levels of inflammatory factors,and reduce the SCORAD scores and the recurrence rate.Moreover,it is superior to single Desloratadine citrate disodium treatment.
万方数据
维普
