Effects of compound Pholcodine oral liquid combined with Azithromycin in the treatment of children with asthmatic bronchitis
Objective:To observe effects of compound Pholcodine oral liquid combined with Azithromycin in the treatment of children with asthmatic bronchitis.Methods:A prospective study was conducted on 72 children with asthmatic bronchitis admitted to this hospital from January 2020 to June 2023.They were divided into control group and observation group according to the random number table method,36 cases in each group.The control group was treated with Azithromycin,while the observation group was treated with compound Pholcodine oral liquid on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms(wheezing,fever,cough)and the hospitalization time,the levels of pulmonary function indexes(respiratory function,airway resistance,airway peak pressure)before and after the treatment,the levels of inflammatory factors[interleukin-6(IL-6),procalcitonin(PCT),high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 97.22%(35/36),which was higher than the control group of 77.78%(28/36),and the difference was statistically significant(P<0.05).The disappearance time of wheezing,cough,fever and hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the airway peak pressure,the respiratory work and the airway resistance in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,hs-CRP,PCT and TNF-α in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compound Pholcodine combined with Azithromycin in the treatment of the children with asthmatic bronchitis can improve the clinical efficacy,promote the recovery of clinical symptoms,improve the lung function and reduce the inflammatory response.Moreover,it is superior to single Azithromycin treatment.
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