Effects of low molecular weight Heparin sodium combined with Dydrogesterone in treatment of patients with threatened abortion
Objective:To observe effects of low molecular weight Heparin sodium combined with Dydrogesterone in treatment of patients with threatened abortion.Methods:The clinical data of 98 patients with threatened abortion admitted to this hospital from March 2019 to October 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,49 cases in each.The control group was treated with Dydrogesterone,while the observation group was treated with low molecular weight Heparin sodium on the basis of that of the control group.Both groups were treated continuously for 1 week.The clinical efficacy,the clinical indicators(vaginal bleeding stop time,abdominal pain disappearance time,progesterone recovery time)levels,the coagulation function indicators[D-dimer(D-D),fibrinogen(FIB),platelet count(PLT)]levels before and after the treatment,the incidence of adverse reactions,and the birth outcomes were compared between the two groups.Results:The total effective rate of the observation group was 95.92%(47/49),which was higher than 83.67%(41/49)of the control group,and the difference was statistically significant(P<0.05).The vaginal bleeding stop time,the abdominal pain disappearance time and the progesterone recovery time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of D-D,FIB and PLT in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The full-term delivery rate in the observation group was 87.76%(43/49),which was higher than 65.31%(32/49)in the control group,and the difference was statistically significant(P<0.05).However,there were no significant differences in the incidence of adverse reactions,the abortion rate and the premature delivery rate between the two groups(P>0.05).Conclusions:Low molecular weight Heparin sodium combined with Dydrogesterone in the treatment of the threatened abortion patients can improve the total effective rate of treatment and the full-term delivery rate,improve the levels of clinical indicators,and reduce the levels of coagulation function indicators.Moreover,it is superior to single Dydrogesterone treatment.
万方数据
维普
