Effects of Danshen injection combined with Aspirin enteric-coated tablets and Ticagrelor tablets on patients with acute ST-segment elevation myocardial infarction after PCI
Objective:To observe effects of Danshen injection combined with Aspirin enteric-coated tablets and Ticagrelor tablets on patients with acute ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods:A prospective study was conducted on 80 patients with STEMI after PCI admitted to this hospital from October 2022 to April 2023.They were divided into study group and control group according to the random number table method,40 cases in each group.The control group was treated with Aspirin enteric-coated tablets combined with Ticagrelor tablets,while the study group was treated with Danshen injection on the basis of that of the control group.The clinical effects,the cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)]levels,serum C-reactive protein(CRP)levels,serum N-terminal pro-brain natriuretic peptide(NT-proBNP)levels,and the renal function indexes[serum creatinine,serum cystatin C,glomerular filtration rate]levels were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.50%,which was significantly higher than 72.50%in the control group,the difference was statistically significant(P<0.05).After the treatment,the levels of LVEF and glomerular filtration rate in the study group were higher than those in the control group,the levels of LVEDD,LVESD,CRP,NT-proBNP,serum creatinine and cystatin C were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Danshen injection combined with Aspirin enteric-coated tablets and Ticagrelor tablets for the STEMI patients after PCI can improve the total effective rate of treatment,improve the levels of cardiac function indexes and renal function indexes,and reduce the levels of serum CRP and NT-proBNP.Moreover,it is superior to Aspirin enteric-coated tablets combined with Ticagrelor tablets treatment.
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维普
