Effects of Compound Kushen injection combined with TP chemotherapy in treatment of patients with advanced esophageal cancer
Objective:To observe effects of Compound Kushen injection combined with TP chemotherapy in treatment of patients with advanced esophageal cancer.Methods:A prospective study was conducted on 78 patients with advanced esophageal cancer admitted to the hospital from January 2019 to January 2023.They were divided into study group and control group according to the random number table method,39 cases in each.The control group was treated with TP chemotherapy regimen,while the study group was treated with compound Kushen injection on the basis of that of the control group.21 d was a course of treatment.Both groups were treated for 4 courses.The clinical efficacy,the levels of tumor markers[squamous cell carcinoma-associated antigen(SCC-Ag),carcinoembryonic antigen(CEA),high mobility group protein B1(HMGB1)],the T cell subset levels(CD4+,CD8+,CD4+/CD8+),and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The disease control rate(DCR)of the study group was 94.87%(37/39),which was higher than 79.49%(31/39)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CEA,SCC-Ag and HMGB1 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD4+ and CD4+/CD8+ in the study group were higher than those in the control group,the level of CD8+ was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions such as leukopenia,liver and kidney dysfunction,thrombocytopenia,and gastrointestinal discomfort between the two groups(P>0.05).Conclusions:Compound Kushen injection combined with TP chemotherapy in the treatment of the patients with advanced esophageal cancer can improve the DCR,reduce the levels of tumor markers,and regulate the levels of T cell subsets.Moreover,it is superior to single TP chemotherapy regimen.
万方数据
维普
