Effects of Qingyi Tongfu decoction retention enema combined with conventional western medicine in treatment of patients with acute pancreatitis complicated with paralytic ileus
Objective:To investigate effects of Qingyi Tongfu decoction retention enema combined with conventional western medicine in treatment of patients with acute pancreatitis(AP)complicated with paralytic ileus(PI).Methods:A prospective study was conducted on 78 patients with AP and PI admitted to the hospital from March 2021 to January 2023.They were divided into observation group and control group according to the random number table method,39 cases in each group.Both groups were given conventional treatment such as fasting,water deprivation,gastrointestinal decompression,and intravenous injection of Octreotide.On this basis,the observation group was treated with Qingyi Tongfu decoction for retention enema,while the control group was treated with normal saline without retention enema.The clinical efficacy,the rehabilitation time,the serum inflammatory factors[C-reactive protein(CRP),procalcitonin(PCT)]levels,the pancreatic function indexes[amylase,transforming growth factor-β1(TGF-β1)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.87%(37/39),which was higher than 79.49%(31/39)of the control group,and the difference was statistically significant(P<0.05).The first exhaust time,the first defecation time and the hospitalization time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum CRP,PCT and amylase in the observation group were lower than those in the control group,the level of TGF-β1 was higher than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Qingyi Tongfu decoction retention enema combined with conventional western medicine has a significant effect on the AP patients with PI,which can accelerate the symptom relief,shorten the hospitalization time,reduce the serum amylase and inflammatory factor levels,promote the pancreatic repair,and increase the TGF-β1 levels.Moreover,it is superior to single western medicine treatment.
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维普
