Effects of Shenqi Guben granules in treatment of children with lung-spleen qi deficiency syndrome in the recovery period of bronchial asthma
Objective:To observe effects of Shenqi Guben granules in treatment of children with lung-spleen qi deficiency syndrome in the recovery period of bronchial asthma.Methods:A prospective study was conducted on 90 children with lung-spleen qi deficiency syndrome in the recovery period of bronchial asthma admitted to Pingdingshan Hospital of Traditional Chinese Medicine from July 2021 to July 2022.They were divided into study group and control group according to the random number table method,45 cases in each group.The control group was treated with Budesonide inhalation aerosol,while the study group was treated with Shenqi Guben granules on the basis of the control group.The clinical efficacy,the TCM syndrome scores before and after the treatment,the lung function indexes[forced expiratory volume in one second(FEV1),peak expiratory flow(PEF)]levels,the immunoglobulin indexes[immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)]levels,the inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-4(IL-4)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.33%(42/45),which was higher than 73.33%(33/45)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as asthma,cough,wheezing,expectoration,and fatigue in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of FEV1 and PEF in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of IgA,IgG and IgM in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of TNF-α,IL-6 and IL-4 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:On the basis of Budesonide inhalation aerosol treatment,Shenqi Guben granules can improve the total effective rate,the lung function index and immunoglobulin index levels,and reduce the TCM syndrome scores and the inflammatory factor levels in the treatment of the children with lung-spleen qi deficiency syndrome in the recovery period of bronchial asthma.Moreover,it is superior to single Budesonide inhalation aerosol treatment.
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