Expression and significance of N-myc downstream regulatory gene 2 and microsatellite instability in gastric cancer patients with different pathological features
Objective:To investigate expression and significance of N-myc downstream regulated gene 2(NDRG2)and microsatellite instability(MSI)in gastric cancer patients with different pathological features.Methods:The clinical data of 98 patients undergoing radical gastrectomy in the hospital from January 2019 to December 2020 were retrospectively analyzed.The detection results of NDRG2 and MSI in the patients with gastric cancer were statistically analyzed.The expression of NDRG2 and MSI in the gastric cancer patients with different pathological features were compared.Results:The positive rate of NDRG2 in the gastric cancer patients with clinical stage Ⅰ-Ⅱ and no lymph node metastasis were higher than those in the patients with clinical stage Ⅲ-Ⅳ and with lymph node metastasis,and the differences were statistically significant(P<0.05).The positive expression rate of MSI in the gastric cancer patients with tumor location in gastric antrum,Lauren intestinal type,low differentiation,clinical stage Ⅰ-Ⅱ,and without lymph node metastasis were high,and the differences were statistically significant(P<0.05).Conclusions:NDRG2 is highly expressed in the gastric cancer patients with clinical stage Ⅰ-Ⅱ and no lymph node metastasis.MSI was highly expressed in the gastric cancer patients with tumor location in the gastric antrum,Lauren intestinal type,low differentiation,clinical stage Ⅰ-Ⅱ,and no lymph node metastasis.Both participate in the occurrence and development of gastric cancer.
万方数据
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