Correlations among serum IL-8,IL-32,TNF-α levels and severity of bacterial pneumonia in children
Objective:To analyze correlations among serum interleukin-8(IL-8),interleukin-32(IL-32),tumor necrosis factor-α(TNF-α)levels and severity of bacterial pneumonia in children.Methods:The clinical data of 106 children with bacterial pneumonia admitted to this hospital from July 2021 to July 2022 were retrospectively analyzed and they set as the observation group.According to the severity of the disease,they were divided into 51 children with severe pneumonia and 55 children with non-severe pneumonia.The clinical data of 106 healthy children who underwent physical examination in the hospital during the same period were retrospectively analyzed and they were set as the control group.The serum levels of IL-8,IL-32 and TNF-α were compared between the observation group and control group groups as well as the children with severe pneumonia and non-severe pneumonia.Spearman correlation analysis was used to analyze the correlations among the serum IL-8,IL-32,TNF-α levels and the severity of bacterial pneumonia in the children.Results:The levels of serum IL-8,IL-32 and TNF-α in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum IL-8,IL-32 and TNF-α in the children with severe pneumonia were higher than those in the children with non-severe pneumonia,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that the serum IL-8,IL-32 and TNF-α levels were positively correlated with the severity of bacterial pneumonia in the children(r>0,P<0.05).Conclusions:The levels of serum IL-8,IL-32 and TNF-α are positively correlated with the severity of bacterial pneumonia in the children.
Bacterial pneumoniaChildrenInterleukin-8Interleukin-32Tumor necrosis factor-αSeverity of diseaseCorrelation
万方数据
维普
