Influencing factors of neonatal congenital hypothyroidism
Objective:To analyze influencing factors of neonatal congenital hypothyroidism.Methods:A cross-sectional study was conducted on 215 neonates born in the hospital from January 2019 to January 2023.The neonatal clinical data and the maternal data were collected.According to whether congenital hypothyroidism occurred,they were divided into occurrence group and non-occurrence group.Logistic regression was used to analyze the influencing factors of neonatal congenital hypothyroidism.Results:Among the 215 neonates,105 had congenital hypothyroidism,with an incidence of 48.84%(105/215).There were no significant differences between the two groups in gender,gravidity,parity,gestational hypertension and gestational diabetes mellitus(P>0.05).The proportions of the neonates with gestational age<37 weeks,birth weight<2.5 kg,fetal distress,maternal age≥35 years old,anxiety during pregnancy,family history of thyroid disease,and history of heavy metal exposure during pregnancy in the occurrence group were higher than those in the non-occurrence group;the proportion of progesterone medication history during pregnancy was lower than that in the non-occurrence group,and the differences were statistically significant(P<0.05).Logistic regression analysis showed that gestational age<37 weeks,birth weight<2.5 kg,fetal distress,maternal age≥35 years old,anxiety during pregnancy,family history of thyroid disease,and history of heavy metal exposure during pregnancy were all risk factors for neonatal congenital hypothyroidism(OR>1,P<0.05),and the history of progesterone medication during pregnancy was a protective factor(OR<1,P<0.05).Conclusions:Gestational age<37 weeks,birth weight<2.5 kg,fetal distress,maternal age≥35 years old,anxiety during pregnancy,family history of thyroid disease,and history of heavy metal exposure during pregnancy are the risk factors for neonatal congenital hypothyroidism,and the history of progesterone medication during pregnancy is the protective factor.
万方数据
维普
