Effects of Pramipexole combined with Doxycycline in treatment of patients with Parkinson's disease
Objective:To observe effects of Pramipexole combined with Doxycycline in treatment of patients with Parkinson's disease.Methods:A prospective study was conducted on 86 patients with Parkinson's disease admitted to the hospital from March 2021 to March 2023.According to the random number table method,they were divided into study group and control group,43 cases in each group.The control group was treated with Doxycycline,while the study group was treated with Pramipexole on the basis of that of the control group.The clinical efficacy,the Hoehn-Yahr staging,the non-motor symptom control[non-motor symptom scale(NMSS)]score,the serum miR-124 and miR-137 levels,the cognitive function[Montreal cognitive assessment(MOCA)]score,the quality of life[Parkinson's quality of life questionnaire(PDQ-39)]score before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 95.35%(41/43),which was higher than 81.40%(35/43)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the Hoehn-Yahr staging in the study group was better than that in the control group,and the difference was statistically significant(P<0.05).The NMSS scores such as the severity and frequency of the disease in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The level of serum miR-124 in the study group was higher than that in the control group,the level of serum miR-137 was lower than that in the control group,and the differences were statistically significant(P<0.05).The MOCA score of the study group was higher than that of the control group,the PDQ-39 score was lower than that of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Pramipexole combined with Doxycycline in the treatment of Parkinson's disease can improve the total effective rate of treatment,the serum miR-124 levels and the MOCA scores,reduce the serum miR-137 levels,the NMSS scores and the PDQ-39 scores,and improve the Hoehn-Yahr staging.Moreover,it is superior to single Doxycycline treatment.
Parkinson's diseaseDoxycyclinePramipexoleCognitive functionQuality of lifeHoehn-Yahr stagingNon-motor symptom
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维普
