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哌拉西林钠他唑巴坦钠治疗神经内科严重感染患者的效果

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目的:观察哌拉西林钠他唑巴坦钠治疗神经内科严重感染患者的效果.方法:选取 2021-2022 年该院收治的 72 例神经内科严重感染患者进行前瞻性研究,按照随机数字表法将其分成对照组与观察组各 36 例.对照组采用头孢他啶治疗,观察组采用哌拉西林钠他唑巴坦钠治疗,两组均连续治疗 10 d.比较两组临床疗效、临床指标(体温恢复正常时间、住院时间、住院费用)水平、治疗前后血清炎性因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平,以及不良反应发生率.结果:观察组治疗总有效率为 100.00%(36/36),高于对照组的 83.33%(30/36),差异有统计学意义(P<0.05);观察组体温恢复正常时间、住院时间均短于对照组,住院费用少于对照组,差异有统计学意义(P<0.05);治疗后,观察组血清CRP、TNF-α、IL-6水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:哌拉西林钠他唑巴坦钠治疗神经内科严重感染患者可提高治疗总有效率,改善临床指标水平,降低炎性因子水平,效果优于头孢他啶治疗.
Effects of Piperacillin sodium and Tazobactam sodium in treatment of patients with severe infection in department of neurology
Objective:To observe effects of Piperacillin sodium and Tazobactam sodium in treatment of patients with severe infection in department of neurology.Methods:A prospective study was conducted on 72 patients with severe infection in Department of Neurology admitted to this hospital from 2021 to 2022.They were divided into control group and observation group according to the random number table method,36 cases in each group.The control group was treated with Ceftazidime,while the observation group was treated with Piperacillin sodium and Tazobactam sodium.Both groups were treated for 10 d.The clinical efficacy,the clinical indicators(body temperature recovery time,hospitalization time,hospitalization expenses)levels,the inflammatory factors[tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(CRP),interleukin-6(IL-6)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 100.00%(36/36),which was higher than 83.33%(30/36)of the control group,and the difference was statistically significant(P<0.05).The body temperature recovery time and the hospitalization time in the observation group were shorter than those in the control group,the hospitalization expenses was less than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,TNF-α and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Piperacillin sodium and Tazobactam sodium in the treatment of the patients with severe infection in department of neurology can improve the total effective rate of treatment,improve the levels of clinical indicators and reduce the levels of inflammatory factors.Moreover,it is superior to Ceftazidime treatment.

Department of NeurologySevere infectionPiperacillin sodium and Tazobactam sodiumCeftazidimeInflammatory factorAdverse reaction

施罗炯、孙静

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南阳市第一人民医院神经内科,河南 南阳 473000

神经内科 严重感染 哌拉西林钠他唑巴坦钠 头孢他啶 炎性因子 不良反应

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(3)
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