Effects of Piperacillin sodium and Tazobactam sodium in treatment of patients with severe infection in department of neurology
Objective:To observe effects of Piperacillin sodium and Tazobactam sodium in treatment of patients with severe infection in department of neurology.Methods:A prospective study was conducted on 72 patients with severe infection in Department of Neurology admitted to this hospital from 2021 to 2022.They were divided into control group and observation group according to the random number table method,36 cases in each group.The control group was treated with Ceftazidime,while the observation group was treated with Piperacillin sodium and Tazobactam sodium.Both groups were treated for 10 d.The clinical efficacy,the clinical indicators(body temperature recovery time,hospitalization time,hospitalization expenses)levels,the inflammatory factors[tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(CRP),interleukin-6(IL-6)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 100.00%(36/36),which was higher than 83.33%(30/36)of the control group,and the difference was statistically significant(P<0.05).The body temperature recovery time and the hospitalization time in the observation group were shorter than those in the control group,the hospitalization expenses was less than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,TNF-α and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Piperacillin sodium and Tazobactam sodium in the treatment of the patients with severe infection in department of neurology can improve the total effective rate of treatment,improve the levels of clinical indicators and reduce the levels of inflammatory factors.Moreover,it is superior to Ceftazidime treatment.
Department of NeurologySevere infectionPiperacillin sodium and Tazobactam sodiumCeftazidimeInflammatory factorAdverse reaction