Effects of Linezolid combined with Polymyxin B and Imipenem in treatment of elderly patients with MDR-AB pneumonia
Objective:To observe effects of Linezolid combined with Polymyxin B and Imipenem in treatment of elderly patients with multidrug-resistant Acinetobacter baumannii(MDR-AB)pneumonia.Methods:A prospective study was conducted on 120 elderly patients with MDR-AB pneumonia admitted to this hospital from January 2022 to January 2023.According to the random number table method,they were divided into observation group and control group,60 cases in each group.The control group was treated with Polymyxin B combined with Imipenem,while the observation group was treated with Linezolid glucose injection on the basis of those of the control group.The total effective rate of treatment,the serum inflammatory factors[interleukin(IL)-6,IL-8,tumor necrosis factor-α(TNF-α)]levels,the peripheral blood T cell subsets indicators(CD3+,CD4+,CD8+,CD4+/CD8+)levels,the lung function indicators[forced vital capacity(FVC),maximum mid-expiratory flow(MMF),peak expiratory flow(PEF)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.00%,which was significantly higher than 83.33%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FVC,MMF,PEF,CD3+,CD4+ and CD4+/CD8+ in the observation group were higher than those in the control group,the levels of IL-6,IL-8,TNF-α and CD8+ were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Linezolid combined with Polymyxin B and Imipenem in the treatment of the elderly patients with MDR-AB pneumonia can improve the total effective rate of treatment and the level of lung function indicators,improve the levels of T cell subsets,and reduce the levels of inflammatory factors.Moreover,it is superior to Polymyxin B combined with Imipenem treatment.
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