Effects of fiberoptic bronchoscopy alveolar lavage combined with conventional drugs in treatment of patients with severe bronchial asthma
Objective:To investigate effects of fiberoptic bronchoscopy alveolar lavage(BAL)combined with conventional drugs in treatment of patients with severe bronchial asthma.Methods:A prospective study was conducted on 105 patients with severe bronchial asthma admitted to the hospital from March 2021 to March 2023.According to the random number table method,they were divided into study group(53 cases)and control group(52 cases).The control group was treated with Budesonide and Salbutamol inhalation treatment,while the study group was treated with BAL on the basis of those of the control group.The clinical efficacy,the asthma symptoms[asthma control test(ACT)]score,the pulmonary function indexes[forced expiratory volume in one second(FEV1),FEV1/forced vital capacity(FVC)ratio(FEV1/FVC)]levels,the arterial blood gas indexes[arterial partial pressure of carbon dioxide(PaCO2),arterial oxygen saturation(SaO2)]levels,the serum inflammatory factors[soluble intercellular adhesion molecule-1(sICAM-1)and soluble E-selectin(sE-SLT)]levels before and after the treatment,and the incidence of adverse reactions/complications were compared between the two groups.Results:The total effective rate of the study group was 90.57%(48/53),which was higher than 73.08%(38/52)of the control group,and the difference was statistically significant(P<0.05).After 2 weeks of treatment,the levels of FEV1,FEV1/FVC,SaO2 and the ACT score in the study group were higher than those in the control group,the levels of PaCO2,serum sICAM-1 and sE-SLT were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions/complications between the two groups(P>0.05).Conclusions:BAL combined with Salbutamol,Budesonide and other conventional drugs has a significant effect on the patients with severe bronchial asthma,which can improve the lung function,improve the blood gas index levels,alleviate the asthma symptoms and reduce the serum inflammatory factors.The effect is better than that of conventional drug therapy alone.
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