Effects of Bifidobacterium triple viable bacteria combined with standard quadruple therapy in treatment of patients with Hp infected chronic gastritis
Objective:To observe effects of Bifidobacterium triple viable bacteria combined with standard quadruple therapy in treatment of patients with Helicobacter pylori(Hp)infected chronic gastritis.Methods:A prospective study was conducted on 85 patients with Hp infected chronic gastritis admitted to the hospital from June 2021 to June 2023.According to the random number table method,they were divided into study group(43 cases)and control group(42 cases).The control group was treated with standard quadruple therapy,while the study group was treated with Bifidobacterium triple viable bacteria powder on the basis of that of the control group.The clinical efficacy,the inflammatory factor[C-reactive protein(CRP),procalcitonin(PCT),calcium adhesion protein E,cyclooxygenase-2(COX-2)]levels,the gastrointestinal function indexes[pepsinogen I(PGⅠ),gastrin-17(G-17),carbohydrate antigen 724(CA724)]levels,the intestinal flora levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the study group was 95.35%(41/43),which was higher than 78.57%(33/42)in the control group,and the difference was statistically significant(P<0.05).The levels of CRP,PCT,COX-2 and cadherin E in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of PGⅠ and G-17 in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the levels of CA724 in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of Bifidobacterium and Clostridium butyricum in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the levels of Enterobacteriaceae in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Bifidobacterium triple viable bacteria combined with standard quadruple therapy in the treatment of the patients with Hp infected chronic gastritis can improve the total effective rate of treatment,improve the gastrointestinal function index and intestinal flora levels,and reduce the levels of inflammatory factor.Moreover,it is superior to single standard quadruple therapy.