Effects of cryoprecipitated coagulation factor combined with fresh frozen plasma in treatment of patients with postpartum hemorrhage due to uterine inertia
Objective:To investigate effects of cryoprecipitated coagulation factor combined with fresh frozen plasma in treatment of patients with postpartum hemorrhage due to uterine inertia.Methods:The clinical data of 66 patients with postpartum hemorrhage due to uterine inertia admitted to the hospital from February 2018 to January 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,33 cases in each.Both groups were given routine treatment such as injection of oxytocin and intrauterine packing gauze.On this basis,the control group was infused with ordinary frozen plasma 10-15 mL/kg,while the observation group was infused with cryoprecipitated coagulation factor 10 U on the basis of that of the control group.The clinical efficacy,the hemostasis time,the vaginal bleeding volume 2 and 6 h after blood transfusion,the hemodynamic indexes[heart rate,mean arterial pressure(MAP)]levels,the coagulation indexes[prothrombin time(PT),thrombin time(TT),fibrinogen(FIB)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 93.94%(31/33),which was higher than 75.76%(25/33)of the control group,and the difference was statistically significant(P<0.05).The hemostasis time of the observation group was shorter than that of the control group,the vaginal bleeding volume 2 and 6 h after blood transfusion was less than that of the control group,and the differences were statistically significant(P<0.05).2 h after blood transfusion treatment,the levels of MAP and FIB in the observation group were higher than those in the control group,the heart rate,PT and TT values were lower than those in the control group,and the differences were statistically significant(P<0.05).No obvious adverse reactions occurred in the two groups.Conclusions:Cryoprecipitated coagulation factor combined with fresh frozen plasma in the treatment of the patients with postpartum hemorrhage due to uterine inertia is significantly effective,which can shorten the hemostasis time,reduce the amount of bleeding,and promote the recovery of blood pressure,heart rate and coagulation function.Moreover,it is superior to single infusion of fresh frozen plasma.
Uterine inertiaPostpartum hemorrhageCryoprecipitated coagulation factorFresh frozen plasmaHemodynamicsCoagulation function
万方数据
维普
