Value of combined detection of serum GM-CSF and IGF-1 levels in diagnosis of adverse pregnancy outcomes in patients with gestational diabetes mellitus
Objective:To analyze value of combined detection of serum granulocyte macrophage-colony stimulating factor(GM-CSF)and insulin growth factor-1(IGF-1)levels in diagnosis of adverse pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods:A total of 83 patients with GDM admitted to this hospital from June 2021 to March 2023 were selected as the study group.According to the pregnancy outcome,they were divided into the patients with adverse outcomes(n=24)and the patients with good outcomes(n=59).Another 160 healthy pregnant women in the same period were selected as the control group.The levels of serum GM-CSF and IGF-1 in the two groups and the GDM patients with different pregnancy outcomes were compared.The receiver operating characteristic(ROC)curve was drawn to analyze the value of single and combined detection of serum GM-CSF and IGF-1 levels in the diagnosis of adverse pregnancy outcomes in the GDM patients.Results:The level of IGF-1 in the study group was lower than that in the control group,the level of GM-CSF was higher than that in the control group,and the differences were statistically significant(P<0.05).The level of IGF-1 in the patients with adverse outcomes was lower than that in the patients with good outcomes,the level of GM-CSF was higher than that in the patients with good outcomes,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the areas under the curve of single and combined detection of serum IGF-1 and GM-CSF levels in the diagnosis of adverse pregnancy outcomes in the GDM patients was 0.821,0.822 and 0.912,respectively,all of which had certain diagnostic value,and the combined detection had the highest diagnostic value.Conclusions:The value of combined detection of serum GM-CSF and IGF-1 levels in the diagnosis of adverse pregnancy outcomes in the GDM patients is higher than that of single detection.