Correlations among serum sPD-L1,CXCL8,SAA levels and severity of cough variant asthma in children
Objective:To analyze correlations among serum levels of soluble programmed cell death 1 ligand 1(sPD-L1),C-X-C chemokine ligand 8(CXCL8),and serum amyloid protein A(SAA)and severity of cough variant asthma(CVA)in children.Methods:The clinical data of 100 children with CVA admitted to this hospital from May 2021 to May 2023 were retrospectively analyzed and they were set as the study group.The clinical data of 100 healthy children in the same period were retrospectively analyzed and they set as the control group.According to the severity of the CVA children at admission,they were divided into moderate CVA children(n=50)and severe CVA children(n=50).The serum levels of sPD-L1,CXCL8 and SAA were compared between the two groups and among the children with different severity at admission and 2 and 4 weeks after the treatment.The correlations among the serum levels of sPD-L1,CXCL8 and SAA and the severity of CVA were analyzed.Results:The levels of serum sPD-L1,CXCL8 and SAA in the study group were higher than those in the control group at admission and 2 and 4 weeks after treatment,and the differences were statistically significant(P<0.05).The levels of serum sPD-L1,CXCL8 and SAA in the children with severe CVA were higher than those in the children with moderate CVA at admission and 2 and 4 weeks after treatment,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum sPD-L1,CXCL8 and SAA levels were positively correlated with the severity of CVA at admission and 2 and 4 weeks after treatment(r>0,P<0.05).Conclusions:The serum sPD-L1,CXCL8 and SAA levels are positively correlated with the severity of CVA in the children.
programmed cell death 1 ligand 1C-X-C chemokine ligand 8serum amyloid protein ASeverity of diseaseCough variant asthmaCorrelation
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