Influencing factors of poor prognosis in patients with brain metastases of lung cancer treated by Gamma knife stereotactic radiotherapy
Objective:To analyze influencing factors of poor prognosis in patients with brain metastases of lung cancer treated by Gamma knife stereotactic radiotherapy.Methods:The clinical data of 121 patients with brain metastases of lung cancer treated with Gamma knife stereotactic radiotherapy in this hospital from January 2022 to January 2023 were retrospectively analyzed.The prognosis of these patients was statistically analyzed.Logistic regression was used to analyze the influencing factors of poor prognosis in the patients with brain metastases of lung cancer treated with Gamma knife stereotactic radiotherapy.Results:Among the 121 cases with brain metastases of lung cancer treated by Gamma knife stereotactic radiotherapy,40 cases had poor prognosis and were set as the poor prognosis group,and 81 cases had good prognosis and were set as the good prognosis group.The proportions of the patients with maximum diameter of brain metastases≥3 cm,serum SCC-Ag≥3.80 ng/mL,serum CYFRA21-1≥7.52 ng/mL,and serum NSE≥50.81 μg/L in the poor prognosis group were higher than those of the good prognosis group,and the differences were statistically significant(P<0.05).The Logistic regression analysis showed that serum SCC-Ag≥3.80 ng/mL and serum NSE≥50.81 μg/L were risk factors for poor prognosis in the patients with brain metastases of lung cancer treated with Gamma knife stereotactic radiotherapy(OR>1,P<0.05).Conclusions:Serum SCC-Ag≥3.80 ng/mL and serum NSE≥50.81 μg/L are the risk factors for poor prognosis in the patients with brain metastases of lung cancer treated with Gamma knife stereotactic radiotherapy.
万方数据
维普
