Effects of Dapagliflozin combined with Metformin in treatment of patients with newly diagnosed type 2 diabetes mellitus
Objective:To observe effects of Dapagliflozin combined with Metformin in treatment of patients with newly diagnosed type 2 diabetes mellitus(T2DM).Methods:A prospective study was conducted on 106 patients with newly diagnosed T2DM admitted to the hospital from May 2021 to April 2023.According to the random number table method,they were divided into observation group(n=53)and control group(n=53).The control group was treated with Metformin,while the observation group was treated with Dapagliflozin on the basis of that of the control group.The clinical efficacy,the levels of glucose metabolism indexes[2 h postprandial blood glucose(2hPG),glycosylated hemoglobin(HbAlc),fasting insulin(FINS),insulin resistance index(HOMA-IR),islet secretion index(HOMA-β)]and inflammatory factors[C-reactive protein(CRP),homocysteine(Hcy)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.34% (50/53),which was higher than 81.13% (43/53)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of HbAlc,2hPG and HOMA-IR in the two groups were lower than those before the treatment,and those in the observation group were lower than those in the control group;the levels of FINS and HOMA-β in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP and Hcy in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Dapagliflozin combined with Metformin in the treatment of the newly diagnosed T2DM patients can improve the total effective rate of treatment,improve the levels of glucose metabolism indexes,and reduce the levels of inflammatory indicators.Moreover,it is superior to single Metformin treatment.
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