Effects of Tiotropium bromide combined with Salmeterol/fluticasone in treatment of patients with asthma-chronic obstructive pulmonary disease overlap syndrome
Objective:To observe effects of Tiotropium bromide combined with Salmeterol/fluticasone in treatment of patients with asthma-chronic obstructive pulmonary disease overlap syndrome(ACOS).Methods:The clinical data of 78 patients with ACOS admitted to this hospital from January 2021 to March 2023 were retrospectively analyzed.They were divided into control group and observation group according to different treatment methods,39 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Salmeterol/fluticasone,while the observation group was treated with Tiotropium bromide on the basis of that of the control group.Both groups were treated for 2 months.The clinical efficacy,the lung function indexes[forced expiratory volume in one second(FEV1),peak expiratory flow(PEF),FEV1/forced vital capacity(FVC)]levels,the blood gas indexes[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)]levels,the serological indexes[interferon-γ(INF-γ),interleukin-6(IL-6),matrix metalloproteinase-9(MMP-9)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 94.87% (37/39),which was higher than 76.92% (30/39)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FEV1,PEF and FEV1/FVC in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the PaO2 level of the observation group was higher than that of the control group,the PaCO2 level was lower than that of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of INF-γ,IL-6 and MMP-9 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tiotropium bromide combined with Salmeterol/fluticasone in the treatment of the ACOS patients can improve the total effective rate of treatment and the levels of lung function indexes,improve the levels of blood gas indexes,and reduce the levels of serological indexes.Moreover,it is superior to single Salmeterol/fluticasone treatment.
万方数据
维普
