Effects of Hydrotalcite combined with quadruple therapy on patients with duodenal ulcer and Helicobacter pylori infection
Objective:To observe effects of Hydrotalcite combined with quadruple therapy on patients with duodenal ulcer(DU)and Helicobacter pylori(Hp)infection.Methods:A prospective study was conducted on 80 patients with DU and Hp infection admitted to the hospital from January 2020 to February 2021.They were divided into control group and observation group according to the random number table method,40 cases in each.The control group was treated with quadruple therapy,while the observation group was treated with Hydrotalcite on the basis of that of the control group.Both groups were treated for 4 weeks.The clinical efficacy,the levels of gastrointestinal hormone indexes[gastrin(GAS),adrenomedullin(AM),motilin(MTL),somatostatin(SS),calcitonin gene-related peptide(CGRP)]and the inflammatory factors[interleukin-1β(IL-1β),interleukin-18(IL-18)]before and after the treatment,the Hp eradication rate,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.00% (38/40),which was higher than 80.00% (32/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of GAS,AM and MTL in the observation group were lower than those in the control group,the levels of SS and CGRP were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-1β and IL-18 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The Hp eradication rate in the observation group was 92.50% (37/40),which was higher than 72.50% (29/40)in the control group,and the difference was statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Hydrotalcite combined with quadruple therapy in the treatment of the DU patients with Hp infection can improve the total effective rate of treatment and the Hp eradication rate,improve the levels of gastrointestinal hormones,and reduce the levels of inflammatory factors.Moreover,it is superior to single quadruple therapy.
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