Application effects of Dexmedetomidine combined with general anesthesia in patients with acute cholecystitis surgery
Objective:To observe application effects of Dexmedetomidine combined with general anesthesia in patients with acute cholecystitis(AC)surgery.Methods:The clinical data of 76 patients with AC who underwent laparoscopic cholecystectomy in the hospital from March 2019 to March 2023 were retrospectively analyzed.They were divided into observation group(n=38)and control group(n=38)according to different anesthesia schemes.The control group was given general anesthesia,while the observation group was combined with Dexmedetomidine anesthesia on the basis of that of the control group.The anesthesia quality,the hemodynamic indexes[mean arterial pressure(MAP),heart rate]levels at different time[before anesthesia(T0),1 min after intubation(T1),skin incision(T2),5 min after pneumoperitoneum(T3),end of the surgery(T4)],the stress reaction indexes[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),cortisol]levels before and after the surgery,and the incidence of adverse reactions within 24 h after the surgery were compared between the two groups.Results:The anesthesia complete block time,the spontaneous breathing recovery time and the directional force recovery time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).At T0,there were no statistically significant differences in the MAP and heart rate levels between the two groups(P>0.05).At T1,T2,and T3,the levels of MAP and heart rate in both groups were lower than at T0,but those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).At T4,the levels of MAP and heart rate in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).1 and 3 days after the surgery,the levels of CRP,TNF-α,IL-6 and cortisol in the two groups were higher than those before the surgery,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Dexmedetomidine combined with general anesthesia can improve the anesthesia quality in the patients with AC surgery,improve the levels of hemodynamic indexes,and reduce the level of stress reaction indexes.Moreover,it is superior to single general anesthesia.
万方数据
维普
