Effects of Camrelizumab combined with intensity modulated conformal radiation therapy in treatment of patients with non-small cell lung cancer
Objective:To observe effects of Camrelizumab combined with intensity modulated conformal radiation therapy in treatment of patients with non-small cell lung cancer(NSCLC).Methods:A prospective study was conducted on 80 patients with NSCLC admitted to the hospital from January 2021 to February 2023.According to the random number table method,they were divided into control group and observation group,40 cases in each group.The control group was treated with intensity modulated conformal radiation therapy,while the observation group was treated with Camrelizumab on the basis of that of the control group.The clinical efficacy,the levels of tumor markers[carbohydrate antigen 125(CA125),protein kinase B(PKB),fatty acid synthase(FAS)],the serological indexes[tumor specific growth factor(TSGF),vascular endothelial growth factor(VEGF),basic fibroblast growth factor(b-FGF)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The objective remission rate(ORR)of the observation group was 72.50% (29/40),which was higher than 50.00% (20/40)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of CA125,PKB and FAS in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TSGF,VEGF and b-FGF in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions such as leukopenia,anemia,thrombocytopenia,radiation pneumonia,nausea and vomiting between the two groups(P>0.05).Conclusions:Camrelizumab combined with intensity modulated conformal radiation therapy in the treatment of the NSCLC patients can improve ORR,reduce the levels of tumor markers and serological indexes.Moreover,it is superior to single intensity modulated conformal radiation therapy.
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