Application effects of cocktail therapy combined with continuous femoral nerve block in postoperative analgesia of patients with malignant bone tumors around the knee joint
Objective:To observe effects of cocktail therapy combined with continuous femoral nerve block(FNB)on postoperative analgesia in patients with malignant bone tumors around the knee joint.Methods:A prospective study was conducted on 107 patients with malignant bone tumors around the knee joint who underwent total knee arthroplasty(TKA)in this hospital from September 2020 to September 2022.They were divided into control group(53 cases)and observation group(54 cases)by using the random number table method.The control group was given FNB analgesia after the surgery,while the observation group was combined with cocktail therapy on the basis of that of the control group.The postoperative pain degree[visual analogue scale for passive motion(PVAS),visual analogue scale for resting state(RVAS)]score,the lower limb microcirculation index[dorsalis pedis artery blood flow,ankle brachial index(ABI)]levels,and the serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP)]level were compared between the two groups.Results:The RVAS and PVAS scores of the observation group 24 and 48 h after the surgery were lower than those of the control group,and the differences were statistically significant(P<0.05).48 h after the surgery,the blood flow of dorsalis pedis artery and ABI in the two groups were lower than those before the surgery,but those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).48 h after the surgery,the levels of TNF-α,IL-6 and CRP in the two groups were higher than those before the surgery,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Cocktail therapy combined with FNB for postoperative analgesia in the patients with malignant bone tumors around the knee joint can improve the levels of lower limb microcirculation indexes,reduce the RVAS scores,the PVAS scores and the serum inflammatory factor levels.Moreover,it is superior to single FNB analgesia.
Cocktail therapyContinuous femoral nerve blockTotal knee arthroplastyMalignant bone tumor around the knee jointSerum inflammatory factorLower limb microcirculation
万方数据
维普
