Application effects of target-controlled infusion of Propofol and Remifentanil combined with Sevoflurane inhalation anesthesia in patients with diabetes mellitus undergoing total laparoscopic hysterectomy
Objective:To observe application effects of target-controlled infusion of Propofol and Remifentanil combined with Sevoflurane inhalation anesthesia in patients with diabetes mellitus undergoing total laparoscopic hysterectomy.Methods:A prospective study was conducted on 80 patients with diabetes mellitus undergoing total laparoscopic hysterectomy admitted to this hospital from January 2021 to March 2023.They were divided into control group and observation group according to the random number table method,40 cases in each group.The control group was given target-controlled infusion of Propofol and Remifentanil total intravenous anesthesia,while the observation group was combined with Sevoflurane intravenous anesthesia on the basis of that of the control group.The levels of anesthesia-related indexes,the oxidative stress indexes[angiotensin I(Ang I),norepinephrine(NE)]levels before and after anesthesia,the blood glucose indexes[glucagon,fasting blood glucose(FPG)]levels,the anesthesia recovery quality score,and the incidence of adverse reactions were compared between the two groups.Results:There was no significant difference in the duration of anesthesia between the two groups(P>0.05).The extubation time and the recovery time of the observation group were shorter than those of the control group,and the differences were statistically significant(P<0.05).6 h after the surgery,the levels of serum Ang I,NE,glucagon and FPG in the two groups were higher than those before anesthesia,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).6 h after the surgery,the scores of consciousness,airway patency and limb activity in the observation group were higher than those 5 min after extubation,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusions:The target-controlled infusion of Propofol and Remifentanil combined with Sevoflurane inhalation anesthesia in the patients with diabetes mellitus undergoing total laparoscopic hysterectomy can shorten the extubation time and the anesthesia recovery time,reduce the levels of oxidative stress indexes and blood glucose indexes,and improve the anesthesia recovery quality scores.Moreover,it is superior to target-controlled infusion of Propofol and Remifentanil total intravenous anesthesia.
Total laparoscopic hysterectomyDiabetes mellitusPropofolRemifentanilSevofluraneInhalation anesthesiaOxidative stress
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维普
