Effects of low molecular weight heparin sodium combined with Nifedipine in treatment of patients with gestational hypertension
Objective:To observe effects of low molecular weight heparin sodium combined with Nifedipine in treatment of patients with gestational hypertension.Methods:A prospective study was conducted on 168 patients with gestational hypertension admitted to this hospital from January 2020 to January 2023.They were divided into control group and study group according to the random number table method,84 cases in each.The control group was treated with Nifedipine,while the study group was treated with low molecular weight heparin sodium on the basis of that of the control group.The pregnancy outcome,the clinical efficacy,the blood pressure(systolic blood pressure,diastolic blood pressure)levels before and after the treatment,the vascular endothelial function indicators[endothelin-1(ET-1),homocysteine(Hcy)]and oxidative stress indicators[malondialdehyde(MDA),superoxide dismutase(SOD)]levels,the platelet aggregation rate and adhesion rate,and the incidence of adverse reactions were compared between the two groups.Results:The vaginal delivery rate of the study group was higher than that of the control group,the cesarean section rate was lower than that of the control group,and the differences were statistically significant(P<0.05).The total effective rate of treatment in the study group was 94.05% (79/84),which was higher than 80.95% (68/84)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of systolic blood pressure and diastolic blood pressure in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of ET-1,Hcy and MDA in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the SOD levels of the two groups were higher than those before the treatment,and that in the study group was higher than that in the control group;and the differences were statistically significant(P<0.05).The platelet aggregation rate and adhesion rate of the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).No obvious adverse reactions occurred in the two groups during the treatment.Conclusions:Low molecular weight heparin sodium combined with Nifedipine in the treatment of the patients with gestational hypertension can improve the pregnancy outcome,improve the clinical efficacy,reduce the blood pressure,inhibit the platelet aggregation,and alleviate the oxidative stress.Moreover,it is superior to single Nifedipine treatment.
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