Application effects of Esketamine intravenous administration combined with Ropivacaine caudal block anesthesia in children with inguinal hernia repair
Objective:To observe application effects of Esketamine intravenous administration combined with Ropivacaine caudal block anesthesia in children with inguinal hernia repair.Methods:A prospective study was conducted on 100 children who underwent inguinal hernia repair in this hospital from September 2022 to January 2023.They were divided into control group and observation group according to the random number table method,50 cases in each group.The control group was treated with Sevoflurane inhalation combined with Ropivacaine caudal block anesthesia,while the observation group was treated with Esketamine intravenous administration combined with Ropivacaine caudal block anesthesia.The hemodynamic index levels(heart rate,respiratory rate,mean arterial pressure)at different time points[before anesthesia(T0),5 min after anesthesia(T1),end of the surgery(T2),2 h after the surgery(T3)],the inflammatory stress index levels[cortisol(Cor),C-reactive protein(CRP),interleukin-6(IL-6)]at different time points(end of the surgery and 6,12 h after the surgery),the clinical indexes(onset time of anesthesia,hospitalization time,postoperative eye opening time,anesthesia recovery room stay time)levels,the postoperative pain[Wong-Baker facial expression scale(WBS)]scores at different time points(2,4,6 h after the surgery),and the incidence of adverse reactions were compared between the two groups.Results:At T1 and T2,the levels of heart rate,respiratory rate and mean arterial pressure of the two groups were lower than those at T0;the levels of heart rate,respiratory rate and mean arterial pressure of the observation group were higher than those of the control group at T1,T2 and T3;and the differences were statistically significant(P<0.05).At 6 and 12 h after the surgery,the levels of Cor,CRP and IL-6 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The postoperative eye opening time and the anesthesia recovery room stay time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).At 2,4,6 h after the surgery,the WBS scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there were no significant differences in the onset time of anesthesia,the hospitalization time and the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Esketamine intravenous administration combined with Ropivacaine caudal block anesthesia in the children with inguinal hernia repair can stabilize the levels of hemodynamic indexes,reduce the levels of postoperative inflammatory stress indexes and the pain scores,and shorten the postoperative eye opening time and the anesthesia recovery room stay time.Moreover,it is superior to Sevoflurane inhalation combined with Ropivacaine caudal block anesthesia.
万方数据
维普
