Effects of human immunoglobulin combined with Acyclovir in treatment of children with viral encephalitis
Objective:To observe effects of human immunoglobulin combined with Acyclovir in treatment of children with viral encephalitis.Methods:A prospective study was conducted on 76 children with viral encephalitis admitted to this hospital from March 2020 to March 2023.According to the random number table method,they were divided into control group and observation group,38 cases in each group.The control group was treated with Acyclovir,while the observation group was treated with human immunoglobulin on the basis of that of the control group.The clinical efficacy,the improvement time of clinical symptoms,the levels of inflammatory factors[procalcitonin(PCT),interferon-γ(INF-γ),interleukin-6(IL-6)],the immune function indexes[immunoglobulin M(IgM),immunoglobulin G(IgG)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.11% (35/38),which was higher than 73.68% (28/38)of the control group,and the difference was statistically significant(P<0.05).The disappearance time of fever,convulsion,dizziness and vomiting and the consciousness recovery time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of PCT,INF-γ and IL-6 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The IgG levels of the two groups were higher than those before the treatment,that in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There were no significant differences in the IgM level and incidence of adverse reactions between the two groups(P>0.05).Conclusions:Human immunoglobulin combined with Acyclovir in the treatment of the children with viral encephalitis can improve the clinical efficacy,promote the recovery of clinical symptoms,reduce the body's inflammatory response,and improve the immune function.Moreover,it is superior to single Acyclovir treatment.