Effects of Feilike mixture combined with Ambroxol hydrochloride and Azithromycin in treatment of elderly patients with mycoplasma pneumonia
Objective:To observe effects of Feilike mixture combined with Ambroxol hydrochloride and Azithromycin in treatment of elderly patients with mycoplasma pneumonia.Methods:A prospective study was conducted on 80 elderly patients with mycoplasma pneumonia admitted to this hospital from January 2020 to January 2022.They were divided into observation group and control group according to the random number table method,40 cases in each group.The control group was treated with Ambroxol hydrochloride combined with Azithromycin,while the observation group was treated with Feilike mixture on the basis of those of the control group.The total effective rate of treatment,the disappearance time of clinical symptoms such as fever,cough,expectoration,lung dry and wet rales and the hospitalization time,the levels of serum inflammatory factors[intercellular adhesion molecule-1(ICAM-1),interleukin-1β(IL-1β)and C-reactive protein(CRP)],the lung function indexes[peak expiratory flow(PEF),forced expiratory volume in one second(FEV1)/forced vital capacity(FVC)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.00% ,which was significantly higher than 72.50% of the control group,and the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms such as fever,cough,expectoration,lung dry and wet rales and the hospitalization time in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum ICAM-1,IL-1β and CRP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV1/FVC and PEF in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Feilike mixture combined with Ambroxol hydrochloride and Azithromycin in the treatment of the elderly patients with mycoplasma pneumonia can improve the total effective rate of treatment and the levels of lung function indexes,shorten the disappearance time of fever,cough,expectoration,lung dry and wet rales and the hospitalization time,and reduce the levels of inflammatory factors.Moreover,it is superior to single Ambroxol hydrochloride and Azithromycin treatment.
万方数据
维普
