Correlations among plasma Hcy,D-dimer,Lp(a),25(OH)D levels and severity of coronary heart disease and cardiac function classification in elderly patients with coronary heart disease
Objective:To observe correlations among plasma homocysteine(Hcy),D-dimer,lipoprotein a[Lp(a)],25-hydroxy vitamin D[25(OH)D]levels and severity of coronary heart disease and cardiac function classification in elderly patients with coronary heart disease.Methods:A cross-sectional study was conducted on 100 elderly patients with coronary heart disease admitted to the hospital from February 2021 to February 2022,and they were set as the coronary heart disease group.In addition,100 healthy subjects were selected for the cross-sectional study and set as healthy group.The levels of plasma Hcy,D-dimer,Lp(a)and 25(OH)D were compared between the two groups.The levels of plasma Hcy,D-dimer,Lp(a)and 25(OH)D in the patients with different severity and different cardiac function classifications in the coronary heart disease group were compared.Spearman correlation analysis was used to analyze the correlations among the plasma Hcy,D-dimer,Lp(a)and 25(OH)D levels and the severity of coronary heart disease and cardiac function classification.Results:The levels of plasma Hcy,D-dimer and Lp(a)in the coronary heart disease group were higher than those in the healthy group,the level of plasma 25(OH)D was lower than that in the healthy group,and the differences were statistically significant(P<0.05).The levels of plasma Hcy,D-dimer and Lp(a)in the patients with severe coronary heart disease were higher than those in the moderate and mild patients,and those in the moderate patients were higher than those in the mild patients;the levels of plasma 25(OH)D in the patients with severe coronary heart disease were lower than those in the moderate and mild patients,and that in the moderate patients was lower than that in the mild patients;and the differences were statistically significant(P<0.05).The levels of plasma Hcy,D-dimer and Lp(a)in the patients with coronary heart disease of New York Heart Association(NYHA)cardiac function classification IV were higher than those in patients with classification III and classification II,and those in the patients with classification III were higher than those in the patients with classification II;the plasma 25(OH)D level in the patients with coronary heart disease of NYHA cardiac function classification IV was lower than those in the patients with classification III and classification II,and that in the patients with classification III was lower than that in the patients with classification II;and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that plasma Hcy,D-dimer and Lp(a)levels were positively correlated with the severity of coronary heart disease and cardiac function classification(r>0,P<0.05),and the plasma 25(OH)D level was negatively correlated with the severity of coronary heart disease and cardiac function classification(r<0,P<0.05).Conclusions:The levels of plasma Hcy,D-dimer and Lp(a)are positively correlated with the severity and cardiac function classification of elderly patients with coronary heart disease,and the level of plasma 25(OH)D is negatively correlated with the severity and cardiac function classification.
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