Pathogenic bacteria distribution and drug resistance in patients with ventilator-associated pneumonia caused by Gram-negative bacilli
Objective:To analyze pathogenic bacteria distribution and drug resistance in patients with ventilator-associated pneumonia(VAP)caused by Gram-negative bacilli.Methods:A prospective study was conducted on 134 patients with VAP caused by Gram-negative bacilli admitted to this hospital from March 2020 to December 2022.Lower respiratory tract secretion specimens were collected.The distribution and drug resistance of Gram-negative bacilli were analyzed.Results:347 strains of pathogenic bacteria were detected in the lower respiratory tract secretions of the 134 patients with VAP caused by Gram-negative bacilli.Among them,the detection rate of Pseudomonas aeruginosa was the highest(101 strains,29.11%),followed by Klebsiella pneumoniae(62 strains,17.87%),Escherichia coli(52 strains,14.99%),Acinetobacter baumannii(49 strains,14.12%).The resistance of Klebsiella pneumoniae to Amikacin,Piperacillin/Tazobactam and Cefotetan were more than 80%.The resistance of Acinetobacter baumannii to Levofloxacin,Ampicillin/Sulbactam and Ampicillin was more than 70%.The resistance of Pseudomonas aeruginosa to Amikacin was 81.19%.The sensitivity of Escherichia coli to Imipenem and Meropenem was 100.00%.Conclusions:Pseudomonas aeruginosa,Klebsiella pneumoniae,Escherichia coli and Acinetobacter baumannii are common pathogens in the VAP patients cause by Gram-negative bacilli,and their drug resistance are high.
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