Effects of Ginkgo biloba extract injection combined with dual antiplatelet therapy on patients with acute cerebral infarction in convalescent period
Objective:To observe the effect of Ginkgo biloba extract injection combined with dual antiplatelet therapy on patients with acute cerebral infarction(ACI)in convalescent period.Methods:The clinical data of 94 patients with ACI in convalescent period admitted to this hospital from February 2021 to February 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,47 cases in each group.Both groups were given lipid-lowering,anti-infection,nerve nutrition and other conventional treatment.On this basis,the control group was treated with dual antiplatelet therapy,while the observation group was treated with Ginkgo biloba extract injection on the basis of that of the control group.The clinical efficacy,the National Institutes of Health stroke scale(NIHSS)score,the serum inflammatory factors[interleukin-6(IL-6),fibrinogen(FIB)]levels,the coagulation function indexes[thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 93.62%(44/47),that of the control group was 82.98%(39/47),and the difference was not statistically significant(P>0.05).The basic cure rate of the observation group was 29.79%(14/47),which was higher than 12.77%(6/47)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FIB,hs-CRP and IL-6 in the observation group were lower than those in the control group,the values of TT,PT and APTT were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ginkgo biloba extract injection combined with dual antiplatelet therapy can improve the clinical efficacy,reduce the neurological impairment,reduce the levels of inflammatory factors and improve the coagulation function in the patients with ACI in convalescent period.Moreover,it is superior to single dual antiplatelet therapy.
Acute cerebral infarctionConvalescent periodGinkgo biloba extractDual anti-plateletNeurological function
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