Effects of Monosialotetrahexosylganglioside combined with immunoglobulin and glucocorticoid in treatment of patients with acute myelitis
Objective:To investigate effects of Monosialotetrahexosylganglioside(GM1)combined with immunoglobulin and glucocorticoid in treatment of patients with acute myelitis.Methods:A prospective study was conducted on 80 patients with acute myelitis admitted to this hospital from January 2020 to March 2023.They were divided into control group and study group according to the random number table method,40 cases in each.The control group was treated with intravenous immunoglobulin combined with Methylprednisolone,while the study group was treated with GM1 injection on the basis of that of the control group.The clinical efficacy,symptom relief time,the serum neurotrophic factors[nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF)]levels,the inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.00%(38/40),which was higher than 77.50%(31/40)in the control group,and the difference was statistically significant(P<0.05).The independent walking time,the independent urination time,the sensory function recovery time and the muscle strength recovery time of the study group were shorter than those of the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of serum NGF and BDNF in the study group were higher than those in the control group,the levels of IL-6,TNF-α and IL-1β were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:GM1 combined with immunoglobulin and glucocorticoid in the treatment of the patients with acute myelitis can improve the clinical efficacy,accelerate the relief of symptoms,reduce the inflammatory response,and improve the levels of neurotrophic factors.Moreover,it is superior to single immunoglobulin combined with glucocorticoid therapy.
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