Effects of Triptorelin combined with laparoscopic hysteromyomectomy in treatment of patients with uterine fibroids
Objective:To observe effects of Triptorelin combined with laparoscopic hysteromyomectomy in treatment of patients with uterine fibroids.Methods:A prospective study was conducted on 96 patients with uterine fibroids admitted to this hospital from April 2020 to January 2023.According to the random number table method,they were divided into control group and observation group,48 cases in each group.The control group was treated with laparoscopic hysteromyomectomy,while the observation group was treated with Triptorelin on the basis of that of the control group.The clinical efficacy,the levels of uterine related indexes(uterine volume,endometrial blood flow resistance index,endometrial thickness)and sex hormone indexes[estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH)]before and after the treatment,and the recurrence rate 6 months after the surgery were compared between the two groups.Results:The total effective rate of the observation group was 97.92%(47/48),which was higher than 70.83%(34/48)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the uterine volume and the endometrial thickness of the two groups were smaller than those before the treatment,and those in the observation group were smaller than those in the control group;the endometrial blood flow resistance index levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).The levels of E2,FSH and LH in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,6 months after the surgery,the recurrence rate of the observation group was 6.25%(3/48),which was lower than 22.92%(11/48)of the control group,and the difference was statistically significant(P<0.05).Conclusions:Triptorelin combined with laparoscopic hysteromyomectomy in the treatment of the patients with uterine fibroids can improve the clinical efficacy,reduce the uterine volume and the endometrial thickness,and reduce the endometrial resistance index and sex hormone index levels.Moreover,it is superior to single laparoscopic hysteromyomectomy.
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