Effects of recombinant human erythropoietin-β injection combined with conventional treatment on premature infants with brain injury
Objective:To observe effects of recombinant human erythropoietin-β injection combined with conventional treatment on premature infants with brain injury.Methods:The clinical data of 86 premature infants with brain injury admitted to this hospital from February 2020 to February 2022 were retrospectively analyzed.According to different treatment options,they were divided into study group and control group,43 cases in each group.The control group was treated with conventional treatment,while the study group was treated with recombinant human erythropoietin-β injection on the basis of that of the control group.The total effective rate of treatment,the neonatal behavioral neurological assessment(NBNA)score,the blood gas analysis indexes[arterial partial pressure of carbon dioxide(PaCO2),pH]levels,and the serum cytokines[hypoxia inducible factor-1α(HIF-1α),neuron-specific enolase(NSE),central nervous system specific protein(S100β),myelin basic protein(MBP)]were compared between the two groups.Results:The total effective rate of the study group was 93.02%,which was significantly higher than 74.42%of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PaCO2,HIF-1α,NSE,S100β and MBP in the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;the pH levels and the NBNA scores of the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;and the differences were statistically significant(P<0.05).Conclusions:Recombinant human erythropoietin-β injection combined with conventional treatment for the premature infants with brain injury can improve the total effective rate of treatment and the NBNA scores,improve the levels of blood gas analysis indexes,and reduce the levels of serum cytokines.Moreover,it is superior to single conventional treatment.
Recombinant human erythropoietin-β injectionPremature infantBrain injuryBlood gas analysisCytokineNBNA score