Application effects of intravenous infusion of Esketamine hydrochloride injection combined with conventional intravenous general anesthesia in children with strabismus correction surgery
Objective:To observe application effects of intravenous infusion of Esketamine hydrochloride injection combined with conventional intravenous general anesthesia in children with strabismus correction surgery.Methods:A prospective study was conducted on 100 children who underwent strabismus correction in this hospital from April 2022 to April 2023.According to the random number table method,they were divided into observation group and control group,50 cases in each group.The control group was treated with routine intravenous general anesthesia,while the observation group was treated with intravenous infusion of Esketamine hydrochloride injection on the basis of that of the control group.The mean arterial pressure(MAP)and the heart rate(HR)at different time[before anesthesia(T1),5 min after anesthesia(T2),beginning correction(T3),end of surgery(T4)],the operation time,the postoperative consciousness recovery time,the incidence of agitation during recovery period,the faces pain scale-revised(FPS-R)scores at different time(2,12,24 h after the surgery)and the incidence of adverse reactions were compared between the two groups.Results:At T2,T3 and T4,the levels of mean arterial pressure and heart rate of the two groups were higher than those at T1,but those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of agitation during the recovery period in the observation group was 4.00%,which was lower than 18.00%in the control group,and the difference was statistically significant(P<0.05).At 2,12 and 24 h after the surgery,the FPS-R scores of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there were no significant differences in the operation time,the postoperative consciousness recovery time and the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Intravenous infusion of Esketamine hydrochloride injection combined with conventional intravenous general anesthesia for the children with strabismus correction surgery can reduce the incidence of agitation,the mean arterial pressure,the heart rate and the FPS-R scores during the recovery period.Moreover,it is superior to single conventional intravenous general anesthesia.
EsketamineGeneral anesthesiaStrabismus correction in childrenAgitationMean arterial pressureHeart rateFPS-R score