首页|乙酰半胱氨酸雾化联合纤维支气管镜肺泡灌洗治疗大叶性肺炎患儿的效果

乙酰半胱氨酸雾化联合纤维支气管镜肺泡灌洗治疗大叶性肺炎患儿的效果

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目的:观察乙酰半胱氨酸雾化联合纤维支气管镜肺泡灌洗治疗大叶性肺炎患儿的效果.方法:选取 2020 年 3 月至 2023 年3月该院收治的112例大叶性肺炎患儿进行前瞻性研究,依照随机数字表法将其分为对照组和研究组各56例.对照组给予纤维支气管镜肺泡灌洗治疗,研究组在对照组基础上联合乙酰半胱氨酸雾化治疗,比较两组临床疗效、症状改善时间和住院时间,治疗前后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、呼气流量峰值(PEF)]水平、炎性指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、降钙素原(PCT)]水平和不良反应发生率.结果:研究组治疗总有效率为96.43%(54/56),高于对照组的82.14%(46/56),差异有统计学意义(P<0.05);研究组咳嗽咳痰消失时间、肺部啰音消失时间、体温恢复时间、肺部影像学改善时间、住院时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组FEV1、FVC、PEF水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05);两组TNF-α、IL-1β、PCT水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:乙酰半胱氨酸雾化联合纤维支气管镜肺泡灌洗治疗大叶性肺炎患儿可提高治疗总有效率和肺功能指标水平,缩短症状改善时间和住院时间,降低炎性指标水平,其效果优于单纯纤维支气管镜肺泡灌洗治疗.
Effects of Acetylcysteine atomization combined with bronchofiberscope alveolar lavage in treatment of children with lobar pneumonia
Objective:To observe effects of Acetylcysteine atomization combined with bronchofiberscope alveolar lavage in treatment of children with lobar pneumonia.Methods:A prospective study was conducted on 112 children with lobar pneumonia admitted to this hospital from March 2020 to March 2023.According to the random number table method,they were divided into control group and study group,56 cases in each group.The control group was treated with bronchofiberscope alveolar lavage,while the study group was treated with Acetylcysteine atomization on the basis of that of the control group.The clinical efficacy,the symptom improvement time and the hospitalization time,the lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),peak expiratory flow(PEF)]levels before and after the treatment,the inflammatory indexes[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),procalcitonin(PCT)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 96.43%(54/56),which was higher than 82.14%(46/56)of the control group,and the difference was statistically significant(P<0.05).The cough and sputum disappearance time,the lung rale disappearance time,the body temperature recovery time,the lung imaging improvement time and the hospitalization time in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV1,FVC and PEF in the two groups were higher than those before the treatment,those in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of TNF-α,IL-1β and PCT in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Acetylcysteine atomization combined with bronchofiberscope alveolar lavage in the treatment of the children with lobar pneumonia can improve the total effective rate of treatment and the levels of lung function indexes,shorten the symptom improvement time and the hospitalization time,and reduce the levels of inflammatory indexes.Moreover,it is superior to single bronchofiberscope alveolar lavage treatment.

Lobar pneumoniaAcetylcysteine atomizationBronchofiberscope alveolar lavageLung functionInflammatory indexesAdverse reaction

吴岩岩

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驻马店市中心医院,河南 驻马店 463000

大叶性肺炎 乙酰半胱氨酸雾化 纤维支气管镜肺泡灌洗 肺功能 炎性指标 不良反应

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(5)
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