Effects of Tongxinluo capsules combined with Potassium magnesium aspartate in treatment of patients with ventricular arrhythmia
Objective:To observe effects of Tongxinluo capsules combined with Potassium magnesium aspartate in treatment of patients with ventricular arrhythmia.Methods:The clinical data of 88 patients with ventricular arrhythmia admitted to this hospital from May 2021 to March 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,44 cases in each group.Both groups were given basic treatment.On this basis,the control group was treated with Potassium magnesium aspartate,while the observation group was treated with Tongxinluo capsules on the basis of that of the control group.Both groups were treated for 4 weeks.The clinical efficacy,the levels of heart rate variability indexes[proportion of adjacent NN intervals differing by>50 ms(PNN50),root mean square successive differences between successive RR intervals(RMSSD),standard deviation of NN intervals(SDNN),standard deviation of mean value of sinus RR intervals every 5 min(SDANN)]and inflammatory indexes[interleukin-6(IL-6),nuclear factor-kappa B(NF-κB),matrix metalloproteinase-9(MMP-9),soluble CD40 ligand(sCD40L)],and the incidence of adverse reactions was compared between two groups before and after the treatment.Results:The total effective rate of the observation group was 95.45%(42/44),which was higher than 81.82%(36/44)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of PNN50,RMSSD,SDNN and SDANN in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,NF-κB,MMP-9 and sCD40L in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tongxinluo capsules combined with Potassium magnesium aspartate in the treatment of the patients with ventricular arrhythmia can improve the total effective rate and the levels of heart rate variability indexes,and reduce the levels of inflammatory indexes.Moreover,it is superior to single Potassium magnesium aspartate treatment.
万方数据
维普
