首页|痰热清注射液联合抗生素降阶梯方案治疗耐药菌感染重症肺炎患者的效果

痰热清注射液联合抗生素降阶梯方案治疗耐药菌感染重症肺炎患者的效果

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目的:观察痰热清注射液联合抗生素降阶梯方案治疗耐药菌感染重症肺炎患者的效果.方法:选取 2020 年 1 月至 2022 年6月该院收治的100例耐药菌感染重症肺炎患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各50例.两组均予以对症治疗,在此基础上,对照组采用抗生素降阶梯方案治疗,观察组在对照组基础上联合痰热清注射液治疗.比较两组临床疗效,治疗前后临床肺部感染评分(CPIS)、肺功能指标[第 1 秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]水平、炎性指标[C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、白细胞计数(WBC)]水平,以及不良反应发生率.结果:观察组治疗总有效率为94.00%(47/50),高于对照组的80.00%(40/50),差异有统计学意义(P<0.05);治疗后,观察组CPIS评分和CRP、PCT、IL-6、WBC水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组FEV1、FVC、FEV1/FVC水平均高于对照组,差异有统计学意义(P<0.05);两组治疗期间均未发生明显不良反应.结论:痰热清注射液联合抗生素降阶梯方案治疗耐药菌感染重症肺炎患者可提高治疗总有效率和肺功能指标水平,降低CPIS评分和炎性指标水平,效果优于单纯抗生素降阶梯方案治疗.
Effects of Tanreqing injection combined with antibiotic de-escalation regimen in treatment of patients with severe pneumonia infected with drug-resistant bacteria
Objective:To observe effects of Tanreqing injection combined with antibiotic de-escalation regimen in treatment of patients with severe pneumonia infected with drug-resistant bacteria.Methods:A prospective study was conducted on 100 patients with severe pneumonia infected by drug-resistant bacteria admitted to the hospital from January 2020 to June 2022.According to the random number table method,they were divided into control group and observation group,50 cases in each group.Both groups were given symptomatic treatment.On this basis,the control group was treated with antibiotic de-escalation regimen,while the observation group was treated with Tanreqing injection on the basis of that of the control group.The clinical efficacy,the clinical pulmonary infection score(CPIS),the lung function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC]levels,the inflammatory indexes[C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6),white blood cell count(WBC)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 94.00%(47/50),which was higher than 80.00%(40/50)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the CPIS score and the levels of CRP,PCT,IL-6 and WBC in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of FEV1,FVC and FEV1/FVC in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).No obvious adverse reactions occurred in the two groups during the treatment.Conclusions:Tanreqing injection combined with antibiotic de-escalation regimen can improve the total effective rate and the lung function index levels,and reduce the CPIS scores and the inflammatory index levels in patients with severe pneumonia caused by drug-resistant bacteria infection.Moreover,it is superior to single antibiotic de-escalation regimen treatment.

Tanreqing injectionAntibiotic de-escalation regimenDrug-resistant bacteria infectionSevere pneumoniaInflammatory reactionLung functionAdverse reaction

潘晶晶、郑旭歌

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汝州市人民医院药械科临床药学室,河南 平顶山 467500

痰热清注射液 抗生素降阶梯方案 耐药菌感染 重症肺炎 炎症反应 肺功能 不良反应

2024

中国民康医学
中国社会工作协会

中国民康医学

影响因子:0.649
ISSN:1672-0369
年,卷(期):2024.36(5)
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